Integrity of airway epithelium is essential against obliterative airway disease in transplanted rat tracheas
N Qu, P de Vos, M Schelfhorst, A de Haan… - The Journal of heart and …, 2005 - Elsevier
BACKGROUND: The pathogenesis of obliterative bronchiolitis after lung transplantation
requires further elucidation. In this study we used rat trachea transplantation to examine the
role of epithelium in the progression of obliterative airway disease. METHODS: Normal and
denuded (ie, epithelium removed) trachea grafts from Lewis (LEW) and Brown Norway (BN)
rats were transplanted sub-cutaneously into LEW rats. Viable trachea epithelial cells (to
recover epithelium) were seeded into the lumen of some of the denuded tracheas. Grafts …
requires further elucidation. In this study we used rat trachea transplantation to examine the
role of epithelium in the progression of obliterative airway disease. METHODS: Normal and
denuded (ie, epithelium removed) trachea grafts from Lewis (LEW) and Brown Norway (BN)
rats were transplanted sub-cutaneously into LEW rats. Viable trachea epithelial cells (to
recover epithelium) were seeded into the lumen of some of the denuded tracheas. Grafts …
