[PDF][PDF] Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2+ ISG20+ natural killer-cell transfer
Y Lin, H Wang, W Wang, S Zeng, Y Zhong, DJ Li - Reproduction, 2009 - Citeseer
Y Lin, H Wang, W Wang, S Zeng, Y Zhong, DJ Li
Reproduction, 2009•CiteseerBoth regulatory T cells and regulatory natural killer (NK) cells may play essential roles in the
maintenance of pregnancy. In this study, we show that a significantly high percentage of
spontaneous embryo loss was observed in both allogeneic and syngeneic pregnant non-
obese diabetic (NOD) mice. The percentage of embryo loss in allogeneic pregnant mice was
further increased by the administration of antiasialo ganglio-N-tetraosylceramide to deplete
NK cells, but was decreased by the adoptive transfer of ITGA2CISG20C (CD49bC CD25C)
maintenance of pregnancy. In this study, we show that a significantly high percentage of
spontaneous embryo loss was observed in both allogeneic and syngeneic pregnant non-
obese diabetic (NOD) mice. The percentage of embryo loss in allogeneic pregnant mice was
further increased by the administration of antiasialo ganglio-N-tetraosylceramide to deplete
NK cells, but was decreased by the adoptive transfer of ITGA2CISG20C (CD49bC CD25C)
Abstract
Both regulatory T cells and regulatory natural killer (NK) cells may play essential roles in the maintenance of pregnancy. In this study, we show that a significantly high percentage of spontaneous embryo loss was observed in both allogeneic and syngeneic pregnant non-obese diabetic (NOD) mice. The percentage of embryo loss in allogeneic pregnant mice was further increased by the administration of antiasialo ganglio-N-tetraosylceramide to deplete NK cells, but was decreased by the adoptive transfer of ITGA2CISG20C (CD49bC CD25C)
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