Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: correlations with …
C Strazielle, R Jazi, Y Verdier, S Qian… - Neurochemistry …, 2009 - Elsevier
Mitochondrial dysfunction and brain metabolic alteration are early neurofunctional aspects
in Alzheimer's disease (AD). Regional brain metabolism was analyzed by cytochrome c
oxidase (COX) histochemistry in PS1-A246E mouse mutants, a model of autosomal
dominant AD overexpressing beta-amyloid (Aβ) peptide without amyloidosis or cell
degeneration. Immunohistochemical samples were analyzed on adjacent sections for
regional Aβ1-42 levels, as well as DNA oxidative damage with 8-hydroxy-2-deoxyguanosine …
in Alzheimer's disease (AD). Regional brain metabolism was analyzed by cytochrome c
oxidase (COX) histochemistry in PS1-A246E mouse mutants, a model of autosomal
dominant AD overexpressing beta-amyloid (Aβ) peptide without amyloidosis or cell
degeneration. Immunohistochemical samples were analyzed on adjacent sections for
regional Aβ1-42 levels, as well as DNA oxidative damage with 8-hydroxy-2-deoxyguanosine …
