Seizures are a serious and debilitating co-morbidity of primary brain tumors that affect most
patients, yet their etiology is poorly understood. In many CNS pathologies, including
epilepsy and brain injury, high levels of extracellular glutamate have been implicated in
seizure generation. It has been shown that gliomas release neurotoxic levels of glutamate
through their high expression of system xc-. More recently it was shown that the surrounding
peritumoral cortex is spontaneously hyperexcitable. In this review, we discuss how gliomas …