Adenosine is a well-characterized endogenous anticonvulsant and seizure terminator of the
brain. Through a combination of adenosine receptor-dependent and-independent
mechanisms, adenosine affects seizure generation (ictogenesis), as well as the
development of epilepsy and its progression (epileptogenesis). Maladaptive changes in
adenosine metabolism, in particular increased expression of the astroglial enzyme
adenosine kinase (ADK), play a major role in epileptogenesis. Increased expression of ADK …