[HTML][HTML] Chymotrypsin-like elastase-1 mediates progressive emphysema in alpha-1 antitrypsin deficiency
AJ Devine, NJ Smith, R Joshi, Q Fan… - … Diseases: Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by
alpha-1antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide
model of AAT-deficient emphysema. Mice with genetic ablation of AAT do not have
emphysema at baseline but develop emphysema with injury and aging. We tested the role of
the CELA1 gene in emphysema development in this genetic model of AAT-deficiency
following tracheal lipopolysaccharide (LPS), 10 months of cigarette smoke exposure, aging …
alpha-1antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide
model of AAT-deficient emphysema. Mice with genetic ablation of AAT do not have
emphysema at baseline but develop emphysema with injury and aging. We tested the role of
the CELA1 gene in emphysema development in this genetic model of AAT-deficiency
following tracheal lipopolysaccharide (LPS), 10 months of cigarette smoke exposure, aging …
[HTML][HTML] CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
AJ Devine, NJ Smith, R Joshi, Q Fan… - Research …, 2023 - ncbi.nlm.nih.gov
Abstract Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by α1-
antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of
AAT-deficient emphysema. Mice with genetic ablation of AAT do not have emphysema at
baseline but develop emphysema with injury and aging. We tested the role of CELA1 in
emphysema development in this genetic model of AAT-deficiency following tracheal
lipopolysacharide (LPS), 8 months of cigarette smoke (CS) exposure, aging, and a low-dose …
antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of
AAT-deficient emphysema. Mice with genetic ablation of AAT do not have emphysema at
baseline but develop emphysema with injury and aging. We tested the role of CELA1 in
emphysema development in this genetic model of AAT-deficiency following tracheal
lipopolysacharide (LPS), 8 months of cigarette smoke (CS) exposure, aging, and a low-dose …
